Citations

 

The culmination of the below trials and evidence provides clinical documentation and support for the asterisked claims:

 

*embrace® is the only treatment proven to remodel long-standing lipohypertrophy (LH) in statistically significant clinical results

*embrace® is the only scar tissue/fibrosis treatment proven to prevent scar formation in multiple, Level 1 randomized controlled trials

  1. Blanco M et al. Prevalence and risk factors of lipohypertrophy in insulin-injecting patients with diabetes. Diabetes Metab. 2013 Oct;39(5):445-53. PMID: 23886784.
  2. Strollo F et al. on behalf of AMD-OSDI Italian Study Group on Injection Techniques. Unexplained Hypoglycaemia and Large Glycaemic Variability: Skin Lipohypertrophy as a Predictive Sign. Diabetes Res Open J. 2016;2(1):24-32. doi:10.17140/DROJ-2-126
  3. Famulla S et al. Insulin Injection Into Lipohypertrophic Tissue: Blunted and More Variable Insulin Absorption and Action and Impaired Postprandial Glucose Control. Diabetes Care. 2016 Sep;39(9):1486-92. PMID: 27411698.
  4. Lim AF et al. The embrace device significantly decreases scarring following scar revision surgery in a randomized controlled trial. Plast ReconstrSurg. 2014 Feb;133(2):398-405. PMID: 24105084.
  5. Longaker MT et al. A randomized controlled trial of the embrace advanced scar therapy device to reduce incisional scar formation. Plast ReconstrSurg. 2014 Sep;134(3):536-546. PMID: 24804638.
  6. Talbott HE et al. A tension offloading patch mitigates dermal fibrosis induced by pro-fibrotic skin injections. Res Sq[Preprint]. 2024 Mar 1:rs.3.rs-3915097. PMID: 38464040.
  7. Mascharak S et al. Modulating Cellular Responses to Mechanical Forces to Promote Wound Regeneration. Adv Wound Care (New Rochelle). 2022 Sep;11(9):479-495. PMID: 34465219.
  8. Yuan Y, Gao J, Ogawa R. Mechanobiology and Mechanotherapy of Adipose Tissue-Effect of Mechanical Force on Fat Tissue Engineering. Plast ReconstrSurgGlob Open. 2016 Jan 7;3(12):e578. PMID: 26894003.
  9. desJardins-Park HE, Wan DC. Leveraging Mechanical Forces to Target Insulin Injection-Induced Lipohypertrophy and Fibrosis. Diabetes Spectr. 2021 Aug;34(3):308-312. PMID: 34511858.
  10. DeVries et al.  A Weekly Tension Offloading Patch for Lipohypertrophy.  85th Scientific Sessions, ADA June 20-23, 2025 | Chicago, IL.

 

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